In the current review, we have observed for the very first time that PLK1-mediated phosphorylation of NFBD1 performs a pivotal position in the regulation of G2/M transition in mammalian cells, and hyper-phosphorylation by PLK1 might contribute to genomic instability and tumorigenesis
Upon DNA injury, ataxia-telangiectasia mutated (ATM) protein kinase is activated by its phosphorylation, and...