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Product name: INCB 024360- Epacadostat
Chemical name: (Z)-N-(3-bromo-4-fluorophenyl)-N-hydroxy-4-(2-(sulfamoylamino)ethylamino)-1,2,5-oxadiazole-3-carboximidamideWeb Site click
MF: C11H13BrFN7O4S
MW: 438.23
CAS NO: 147-24-0 Product: Diphenhydramine (hydrochloride)
Purity: 98%
Soluble: Soluble in DMSOHistone Demethylase inhibitors
Description: Potentcompetitiveinhibitorofindoleamine2,3-dioxygenase(IDO1,IC50value72nMinvitro)withinvivopharmacodynamicactivityandefficacyinamousemelanomamodel;INCB024360(Epacadostat)decreasedkynureninelevelsby>50%inplasmaandinhibitedB16-GM-CSFtumorgrowthinadosedepPubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/22311936

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Author: haoyuan2014