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Product name: SJ 172550
Chemical name: (E/Z)-methyl 2-(2-chl or o-6-ethoxy-4-((3-methyl-5-oxo-1-phenyl-1H-pyrazol-4(5H)-ylidene)methyl)phenoxy)acetateWeb Site click
MF: C22H21ClN2O5
MW: 428.87
C AS NO: 107868-30-4 Product: Exemestane
Purity: 99%
Soluble: Soluble in DMSOProte AS ome Inhibitor s
Description: FirstSmall molecule Inhibitor of MDMXwith 10-foldselectivityovercloselyrelatedMDM2(EC50 2.3μMvs26.0μM)which effectivelykillsMDMX-amplifiedretinobl AS to macell s.SJ172550reversiblybindsthe p53-bindingpocke to f MDM,dis ruptsthe MDMX-p53interaction, and the reby freesp53PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/22331245

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