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Se. Kidney Int 68:237245. 20. de Vinuesa SG, Goicoechea M, Kanter J, 18055761 Puerta M, Cachofeiro V, et al Insulin resistance, inflammatory biomarkers, and adipokines in individuals with chronic kidney illness: Effects of angiotensin II blockade. J Am Soc Nephrol 17:S206S212. 21. Coussens LM, Werb Z Inflammation and cancer. Nature 420:860867. 22. Jorgensen L, Heuch I, Jenssen T, Jacobsen BK Association of albuminuria and cancer incidence. J Am Soc Nephrol 19:992998. 23. Cengiz K Improved incidence of neoplasia in chronic renal failure. Int Urol Nephrol 33:121126. 24. Wong G, Hayen A, Chapman JR, Webster AC, Wang JJ, et al Association of CKD and cancer threat in older persons. J Am Soc Nephrol. 6:1341 1350. 25. Grimm RH Jr, Neaton JD, Ludwig W Prognostic significance on the white blood cell count for coronary, cancer, and all-cause mortality. JAMA 254:1932 1937. 26. Friedman GD, Fireman BH The leukocyte count and cancer mortality. Am J Epidemiol 133:376380. 27. Shankar A, Wang JJ, Rochtchina E, Yu MC, Kefford R, et al Association between circulating white blood cell count and cancer mortality: A populationbased cohort study. Arch Intern Med 166:188194. 28. Krepinsky J, Ingram AJ, Clase CM Prolonged sulfonylurea- induced hypoglycemia in diabetic individuals with endstage renal disease. Am J Kidney Dis 35:500505. 29. Schumacher S, Abbasi I, Weise D, Hatorp V, Sattler K, et al Single- and multiple-dose pharmacokinetics of repaglinide in individuals with variety two diabetes and renal impairment. Eur J Clin Pharmacol 57:147152. 30. Yale JF Oral antihyperglycemic agents and renal illness: new agents, new concepts. J Am Soc Nephrol. 16 Suppl 1:S710. 31. Gan SC, Barr J, Arieff AI, Pearl RG Biguanide-associated lactic acidosis. Case report and evaluation from the literature. Arch Intern Med 152:23332336. 32. Chapelsky MC, Thompson-Culkin K, Miller AK, Sack M, Blum R, et al. Pharmacokinetics of rosiglitazone in sufferers with varying degrees of renal insufficiency. J Clin Pharmacol 43:252259. 33. Fried LF, Shlipak MG, Crump C, Bleyer AJ, Gottdiener JS, et al Renal insufficiency as a predictor of cardiovascular outcomes and purchase 1113-59-3 mortality in elderly folks. J Am Coll Cardiol 41:13641372. 34. Shlipak MG, Simon JA, Grady D, Lin F, Wenger NK, et al Heart and Estrogen/progestin Replacement Study Investigators: Renal insufficiency and cardiovascular events in postmenopausal females with CAL 120 chemical information coronary heart disease. J Am Coll Cardiol 38:705711. 35. Mann JF, Gerstein HC, Pogue J, Bosch J, Yusuf S Renal insufficiency as a predictor of cardiovascular outcomes as well as the influence of ramipril: The HOPE randomized trial. Ann Intern Med 134:629636. 36. Schneider CA, Ferrannini E, Defronzo R, Schernthaner G, Yates J, et al Impact of pioglitazone on cardiovascular outcome in diabetes and chronic kidney illness. J Am Soc Nephrol 19:182187. 37. Fox CS, Larson MG, Leip EP, Meigs JB, Wilson PW, et al Glycemic status and improvement of kidney illness: The Framingham Heart Study. Diabetes Care 28:24362440. 38. Perkins BA, Nelson RG, Ostrander BE, Blouch KL, Krolewski AS, et al Detection of renal function decline in patients with diabetes and regular or elevated GFR by serial measurements of serum cystatin C concentration: benefits of a 4-year follow-up study. J Am Soc Nephrol 16:14041412. 39. Davies DF, Shock NW Age alterations in glomerular filtration rate, productive renal plasma flow, and tubular excretory capacity in adult males. J Clin Invest 29:496507. 8 ~~ ~~ Lung cancer is now the major cause of cancer-relate.Se. Kidney Int 68:237245. 20. de Vinuesa SG, Goicoechea M, Kanter J, 18055761 Puerta M, Cachofeiro V, et al Insulin resistance, inflammatory biomarkers, and adipokines in individuals with chronic kidney illness: Effects of angiotensin II blockade. J Am Soc Nephrol 17:S206S212. 21. Coussens LM, Werb Z Inflammation and cancer. Nature 420:860867. 22. Jorgensen L, Heuch I, Jenssen T, Jacobsen BK Association of albuminuria and cancer incidence. J Am Soc Nephrol 19:992998. 23. Cengiz K Enhanced incidence of neoplasia in chronic renal failure. Int Urol Nephrol 33:121126. 24. Wong G, Hayen A, Chapman JR, Webster AC, Wang JJ, et al Association of CKD and cancer threat in older men and women. J Am Soc Nephrol. 6:1341 1350. 25. Grimm RH Jr, Neaton JD, Ludwig W Prognostic value from the white blood cell count for coronary, cancer, and all-cause mortality. JAMA 254:1932 1937. 26. Friedman GD, Fireman BH The leukocyte count and cancer mortality. Am J Epidemiol 133:376380. 27. Shankar A, Wang JJ, Rochtchina E, Yu MC, Kefford R, et al Association in between circulating white blood cell count and cancer mortality: A populationbased cohort study. Arch Intern Med 166:188194. 28. Krepinsky J, Ingram AJ, Clase CM Prolonged sulfonylurea- induced hypoglycemia in diabetic sufferers with endstage renal illness. Am J Kidney Dis 35:500505. 29. Schumacher S, Abbasi I, Weise D, Hatorp V, Sattler K, et al Single- and multiple-dose pharmacokinetics of repaglinide in patients with form two diabetes and renal impairment. Eur J Clin Pharmacol 57:147152. 30. Yale JF Oral antihyperglycemic agents and renal illness: new agents, new concepts. J Am Soc Nephrol. 16 Suppl 1:S710. 31. Gan SC, Barr J, Arieff AI, Pearl RG Biguanide-associated lactic acidosis. Case report and critique of your literature. Arch Intern Med 152:23332336. 32. Chapelsky MC, Thompson-Culkin K, Miller AK, Sack M, Blum R, et al. Pharmacokinetics of rosiglitazone in individuals with varying degrees of renal insufficiency. J Clin Pharmacol 43:252259. 33. Fried LF, Shlipak MG, Crump C, Bleyer AJ, Gottdiener JS, et al Renal insufficiency as a predictor of cardiovascular outcomes and mortality in elderly folks. J Am Coll Cardiol 41:13641372. 34. Shlipak MG, Simon JA, Grady D, Lin F, Wenger NK, et al Heart and Estrogen/progestin Replacement Study Investigators: Renal insufficiency and cardiovascular events in postmenopausal women with coronary heart disease. J Am Coll Cardiol 38:705711. 35. Mann JF, Gerstein HC, Pogue J, Bosch J, Yusuf S Renal insufficiency as a predictor of cardiovascular outcomes as well as the impact of ramipril: The HOPE randomized trial. Ann Intern Med 134:629636. 36. Schneider CA, Ferrannini E, Defronzo R, Schernthaner G, Yates J, et al Effect of pioglitazone on cardiovascular outcome in diabetes and chronic kidney disease. J Am Soc Nephrol 19:182187. 37. Fox CS, Larson MG, Leip EP, Meigs JB, Wilson PW, et al Glycemic status and improvement of kidney illness: The Framingham Heart Study. Diabetes Care 28:24362440. 38. Perkins BA, Nelson RG, Ostrander BE, Blouch KL, Krolewski AS, et al Detection of renal function decline in patients with diabetes and standard or elevated GFR by serial measurements of serum cystatin C concentration: benefits of a 4-year follow-up study. J Am Soc Nephrol 16:14041412. 39. Davies DF, Shock NW Age adjustments in glomerular filtration rate, helpful renal plasma flow, and tubular excretory capacity in adult males. J Clin Invest 29:496507. 8 ~~ ~~ Lung cancer is now the leading cause of cancer-relate.

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