Al Postcentral Supramargil Superiorparietal Inferiorparietal Paracentral Posteriorcingulate Isthmuscingulate Precuneus Cuneus Pericalcarine

Al Postcentral Supramargil Superiorparietal Inferiorparietal Paracentral Posteriorcingulate Isthmuscingulate Precuneus Cuneus Pericalcarine Lingual Lateraloccipital Transversetemporal Bankssts Superiortemporal Middletemporal Inferiortemporal Temporalpole Entorhil Parahippocampal Fusiform Thalamus Caudate Putamen Pallidum Hippocampus Amygdala Accumbens Superiorfrontal Frontalpole rostralmiddlefrontal Caudalmiddlefrontal Parsorbitalis Lateralorbitofrontal Parstriangularis Parsopercularis Medialorbitofrontal Rostralanteriorcingulate Caudalanteriorcingulate Insula Precentral Postcentral Supramargil Superiorparietal Inferiorparietal Paracentral Posteriorcingulate Isthmuscingulate Precuneus Modules CTR I I I III III I III III I I I I III III I III III III I I III III III III III III III III III III I II IV I II II II II II II II I I I III I I III III I I I I III III I III III III I I III Modules sMCI III I II III I I I I I I II II I III I III III III II II III III III II III I III II II II II II II II II II II II II II II III I III III I I I III I I I II I III III III III III III III III Modules lMCIc III III III III III I III III I I I I III III III III III III III I III III III III III III III II I I II II II II II II II II II II II III III III III III I III III III I I I III III III III III III I I III Modules eMCIc III I III III I I III III I I I I III III III III III III III III III III III III III III III III I III II II II III II II II II II II II I I I III I II I III II I I II III III III III III III III II III Modules AD III I III III I I I I I I I I III III III III III III I I III III III III III III III III III III V V V III VI II II II V V II I I I III I I I III I I I I III III III III III III I I IIIContinued Cerebral Cortex,, Vol., No.Table ContinuedHemisphere CF-102 Correct Right Proper Correct Right Proper Appropriate Correct Correct Ideal Suitable Correct Appropriate Ideal Correct Suitable Right Ideal Ideal Proper Brain region Cuneus Pericalcarine Lingual Lateraloccipital Transversetemporal Bankssts Superiortemporal Middletemporal Inferiortemporal Temporalpole Entorhil Parahippocampal Fusiform Thalamus Caudate Putamen Pallidum Hippocampus Amygdala Accumbens Modules CTR III III III III III III I I III I II IV I II II II II II II II Modules sMCI III III III III I III II I II II II II II II II II II II II II Modules lMCIc III III III III I I II II I II II II II II II II II II II II Modules eMCIc III III III III III III II II II II II II II II II II II II II II Modules AD III III III III III III V V I V V V V VI II II II V V IINote: CTR, controls; sMCI, stable mild cognitive impairment; lMCIc, late mild cognitive impairment converters; eMCIc, early mild cognitive impairment converters; AD, Alzheimer’s disease.Table Differences within the withinmodule degree and (-)-DHMEQ biological activity Participation coefficient amongst groups Withinmodule degree Region Rh Pars operculari Withinmodule degree Area Lh Postcentral G Lh Superior Parietal G Withinmodule degree Area Lh Postcentral G Lh Superior Parietal G Lh Superior Temporal PubMed ID:http://jpet.aspetjournals.org/content/131/1/91 G Rh Pars Operculari Participation coefficient Area Lh Lateral Occipital G Rh Postcentral G Rh Lateral Occipital G CTR lMCIc P worth. CTR . . CTR . . . CTR. eMCIc. AD.. AD.. P value. P value.. P worth..Note: CTR, controls; sMCI, steady mild cognitive impairment; lMCIc, late mild cognitive impairment converters; eMCIc, early mild cognitive impairment converters; AD, Alzheimer’s illness; Lh, left hemisphere; Rh, right hemisphere; G, gyrus. Differences among controls and AD pat.Al Postcentral Supramargil Superiorparietal Inferiorparietal Paracentral Posteriorcingulate Isthmuscingulate Precuneus Cuneus Pericalcarine Lingual Lateraloccipital Transversetemporal Bankssts Superiortemporal Middletemporal Inferiortemporal Temporalpole Entorhil Parahippocampal Fusiform Thalamus Caudate Putamen Pallidum Hippocampus Amygdala Accumbens Superiorfrontal Frontalpole rostralmiddlefrontal Caudalmiddlefrontal Parsorbitalis Lateralorbitofrontal Parstriangularis Parsopercularis Medialorbitofrontal Rostralanteriorcingulate Caudalanteriorcingulate Insula Precentral Postcentral Supramargil Superiorparietal Inferiorparietal Paracentral Posteriorcingulate Isthmuscingulate Precuneus Modules CTR I I I III III I III III I I I I III III I III III III I I III III III III III III III III III III I II IV I II II II II II II II I I I III I I III III I I I I III III I III III III I I III Modules sMCI III I II III I I I I I I II II I III I III III III II II III III III II III I III II II II II II II II II II II II II II II III I III III I I I III I I I II I III III III III III III III III Modules lMCIc III III III III III I III III I I I I III III III III III III III I III III III III III III III II I I II II II II II II II II II II II III III III III III I III III III I I I III III III III III III I I III Modules eMCIc III I III III I I III III I I I I III III III III III III III III III III III III III III III III I III II II II III II II II II II II II I I I III I II I III II I I II III III III III III III III II III Modules AD III I III III I I I I I I I I III III III III III III I I III III III III III III III III III III V V V III VI II II II V V II I I I III I I I III I I I I III III III III III III I I IIIContinued Cerebral Cortex,, Vol., No.Table ContinuedHemisphere Ideal Proper Appropriate Proper Right Appropriate Right Right Appropriate Correct Appropriate Correct Proper Ideal Proper Appropriate Proper Ideal Suitable Correct Brain area Cuneus Pericalcarine Lingual Lateraloccipital Transversetemporal Bankssts Superiortemporal Middletemporal Inferiortemporal Temporalpole Entorhil Parahippocampal Fusiform Thalamus Caudate Putamen Pallidum Hippocampus Amygdala Accumbens Modules CTR III III III III III III I I III I II IV I II II II II II II II Modules sMCI III III III III I III II I II II II II II II II II II II II II Modules lMCIc III III III III I I II II I II II II II II II II II II II II Modules eMCIc III III III III III III II II II II II II II II II II II II II II Modules AD III III III III III III V V I V V V V VI II II II V V IINote: CTR, controls; sMCI, stable mild cognitive impairment; lMCIc, late mild cognitive impairment converters; eMCIc, early mild cognitive impairment converters; AD, Alzheimer’s illness.Table Variations in the withinmodule degree and participation coefficient among groups Withinmodule degree Area Rh Pars operculari Withinmodule degree Region Lh Postcentral G Lh Superior Parietal G Withinmodule degree Area Lh Postcentral G Lh Superior Parietal G Lh Superior Temporal PubMed ID:http://jpet.aspetjournals.org/content/131/1/91 G Rh Pars Operculari Participation coefficient Region Lh Lateral Occipital G Rh Postcentral G Rh Lateral Occipital G CTR lMCIc P worth. CTR . . CTR . . . CTR. eMCIc. AD.. AD.. P value. P value.. P value..Note: CTR, controls; sMCI, steady mild cognitive impairment; lMCIc, late mild cognitive impairment converters; eMCIc, early mild cognitive impairment converters; AD, Alzheimer’s disease; Lh, left hemisphere; Rh, right hemisphere; G, gyrus. Differences between controls and AD pat.