N or group”. Health-related stigma has been reported in a number of chronic illnesses, including narcolepsy[2] and is identified as a potential predictor of lower health-related quality of life (HRQOL) and health disparities[3]. Health-related stigma has been associated with lower quality of life in people with chronic illnesses such as Parkinson’s disease[4,5] and epilepsy[6], but has yet to be examined in people with narcolepsy. Narcolepsy is a chronic, incurable neurologic disorder characterized by some or all of the following symptoms, in order of frequency: excessive daytime sleepiness (EDS), cataplexy, hallucinations upon awakening or going to sleep, sleep paralysis, and disturbed nighttime sleep [4,5]. Among these symptoms, EDS and WP1066 side effects cataplexy usually present the greatest challenge to the patient and treating physician alike. Medical treatment includes drugs which: (1) suppress the EDS (amphetamines; modafinil/armodafinil; sodium oxybate); and (2) suppress cataplexy and sleep paralysis (sodium oxybate; antidepressants). Whereas the age range of onset of many chronic medical conditions such as mental illness, physical disability and HIV/AIDS is variable, narcolepsy is notable for an overall bimodal temporal pattern of onset, with the major peak at about 15 years and a minor one at 35 years[6]. The post-adolescent through young adulthood period is an important formative time during which people are not only preparing for and launching a career through a successful educational program, but are also acquiring the self-confidence and skills necessary for an ultimately effective and satisfying social integration. However, despite the usually early onset of the signs of narcolepsy, some individuals may remain symptomatic for 20 years or more before a correct diagnosis and appropriate treatment are achieved, despite repeated encounters with different health care providers[5]. Thus, the young adult with narcolepsy may become stigmatized in one of two ways: because of the absence of a medical explanation for the disruptive episodes of sleepiness, or because of the confirmed presence of a diagnosis that itself may generate stigmatization. Health-related stigma has the potential to limit healthy psychosocial development in a number of important areas. order (S)-(-)-Blebbistatin studies have reported low health-related quality of life in people with narcolepsy[7?3], but most of what is known comes from surveys of adults over a wide range of ages or who are middle-aged or older. Marital difficulties are common[14] and depression frequently occurs[11,14]. Recent studies of adults in their 30’s[15,16] reported low health-related quality of life in younger adult narcolepsy patients with depression and occupational and academic difficulties including deleterious effects on personal and social relations. Patients diagnosed earlier perceived their health as better, attained higher educational level and had less employment problems than those diagnosed later in life[16]. While there is, therefore, considerable evidence of low health-related quality of life in adults with narcolepsy, the actual underlying mechanisms contributing to it have yet to be fully defined. Young adults with narcolepsy have reported feeling set apart (even by members of their own family), inferior to others because of their disorder symptoms, and hesitant to disclose their disorder to others because of fears about the consequences and reaction they would receive[17]. Given the intensive symptoms of narcole.N or group”. Health-related stigma has been reported in a number of chronic illnesses, including narcolepsy[2] and is identified as a potential predictor of lower health-related quality of life (HRQOL) and health disparities[3]. Health-related stigma has been associated with lower quality of life in people with chronic illnesses such as Parkinson’s disease[4,5] and epilepsy[6], but has yet to be examined in people with narcolepsy. Narcolepsy is a chronic, incurable neurologic disorder characterized by some or all of the following symptoms, in order of frequency: excessive daytime sleepiness (EDS), cataplexy, hallucinations upon awakening or going to sleep, sleep paralysis, and disturbed nighttime sleep [4,5]. Among these symptoms, EDS and cataplexy usually present the greatest challenge to the patient and treating physician alike. Medical treatment includes drugs which: (1) suppress the EDS (amphetamines; modafinil/armodafinil; sodium oxybate); and (2) suppress cataplexy and sleep paralysis (sodium oxybate; antidepressants). Whereas the age range of onset of many chronic medical conditions such as mental illness, physical disability and HIV/AIDS is variable, narcolepsy is notable for an overall bimodal temporal pattern of onset, with the major peak at about 15 years and a minor one at 35 years[6]. The post-adolescent through young adulthood period is an important formative time during which people are not only preparing for and launching a career through a successful educational program, but are also acquiring the self-confidence and skills necessary for an ultimately effective and satisfying social integration. However, despite the usually early onset of the signs of narcolepsy, some individuals may remain symptomatic for 20 years or more before a correct diagnosis and appropriate treatment are achieved, despite repeated encounters with different health care providers[5]. Thus, the young adult with narcolepsy may become stigmatized in one of two ways: because of the absence of a medical explanation for the disruptive episodes of sleepiness, or because of the confirmed presence of a diagnosis that itself may generate stigmatization. Health-related stigma has the potential to limit healthy psychosocial development in a number of important areas. Studies have reported low health-related quality of life in people with narcolepsy[7?3], but most of what is known comes from surveys of adults over a wide range of ages or who are middle-aged or older. Marital difficulties are common[14] and depression frequently occurs[11,14]. Recent studies of adults in their 30’s[15,16] reported low health-related quality of life in younger adult narcolepsy patients with depression and occupational and academic difficulties including deleterious effects on personal and social relations. Patients diagnosed earlier perceived their health as better, attained higher educational level and had less employment problems than those diagnosed later in life[16]. While there is, therefore, considerable evidence of low health-related quality of life in adults with narcolepsy, the actual underlying mechanisms contributing to it have yet to be fully defined. Young adults with narcolepsy have reported feeling set apart (even by members of their own family), inferior to others because of their disorder symptoms, and hesitant to disclose their disorder to others because of fears about the consequences and reaction they would receive[17]. Given the intensive symptoms of narcole.
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Cathepsins
