Ected and differentiated EGCs. Disclosure of Interest: None declaredP Safety AND EFFICACY OF A new THERAPEUTIC LASER System FOR HEMOSTATIC Treatment options IN LUMINAL GI ENDOSCOPY First Results IN AN ESTABLISHED ANIMAL MODEL G. E. Tontini,H. Neumann,L. Carmignani,B. Bruni,L. Pastorelli,,F. Cavallaro,F. Fagnani,C. Clemente,M. Bottani,M. Vecchi,Gastroenterology and Digestive Endoscopy Unit,IRCCS Policlinico San Donato,Milano,Italy,Department of Medicine I,University of ErlangenNuremberg,Erlangen,Germany,Academic Urology Department,Pathology and Citodiagnostic Unit,IRCCS Policlinico San Donato,Department of Biomedical Sciences for Well being,University of Milan,Milano,Surgical Division,Quanta Technique S.p.A,Varese,Italy Speak to Email Address: gianeugeniotontinilibero.it Introduction: The Thulium laser method is definitely an established therapeutic technology for surgical resection . The wavelength of mm is strongly absorbed by water present in soft organic tissues,thereby delivering constant speed of cutting and vaporization (i.e. “vaporesection”) irrespective of vascularization,with high degree of manage on the penetration depth .mm) to decrease the risk of inadvertent deep injury. Even so,no study has yet reported its use for reaching hemostasis in the luminal gastrointestinal (GI) tract. Aims Approaches: We performed a pilot study in an established animal model to test for the very first time the security and efficacy of the Thulium Laser method (Cyber TM Quanta Program,Varese,Italy) for hemostatic therapy in luminal PD-1/PD-L1 inhibitor 1 web GIendoscopy. Thus,numerous optical fibers ( and um) were evaluated with unique energy settings (,,and watts),and diverse configurations (continued laser shaping or pulse modality). Study endpoint was to assess the influence in the device with regards to depth penetration and lateral tissue harm beneath a laser exposure prolonged for ,and seconds at fixed distance cm) from the mucosal surface. Outcomes were in comparison to the effect of Argon Plasma Coagulation (APC) generated by an established standard electrosurgery system for hemostatic therapy within the luminal GItract using a . mm catheter utilizing ,and watts. All procedures were performed making use of a regular videogastroscope and digitally recorded. Histopathological analysis based on the entire stomach were performed by an specialist GI pathologist. Benefits: Neither transmural perforation,nor any muscular layer damage was observed PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/28550243 with both systems utilised. A progressive penetration depth and tissue damage was observed with increased laser energy and APC settings,too as with prolonged tissue exposure. Nonetheless,both the fiber diameter and also the configuration modality of the laser system had been located to have no influence on depth penetration and tissue harm,with only marginal impact on the lateral spread of vaporization. General,the laser program has been correlated with comparable degree of vertical tissue injury (from . to . mm),having a a lot much more precise impact on target in accordance with a decrease lateral spreading harm (mm and ..mm applying the and um fiber,respectively) when compared with APC . mm). Conclusion: The Thulium laser technique appears to be secure and helpful for hemostatic therapy in an ex vivo animal model of your upper GItract. In vivo studies need to now confirm these initial results within a prospective setting. References . Rieken M Bachmann A. Nat Rev Urol . . Carmignani L,et al. Asian J Androl . . Marulli G,et al. Lasers Med Sci . Disclosure of Interest: None declaredP 1st STUDY ON A brand new THERAPEUTIC LASER System FOR PERO.