Iary stent insertion achieves adequate palliation. Predictive components of clinical achievement,procedural complications and longterm survival call for further elucidation,particularly in the setting of novel procedural approaches to drainage. Aims Techniques Aims: To identify predictive variables of clinical outcome following technically prosperous biliary drainage following either percutaneous transhepatic (PTBD) or endoscopic ultrasoundguided (EUSBD) access in individuals with unresectable MBO and failed ERCP. Approaches: Baseline capabilities and clinical course of individuals with unresectable MBO drained by PTBD or EUSBD at two tertiary centers have been retrospectively analyzed. Binary uni and multivariate logistic regression analysis was carried out for the following dependent variables: technical good results,clinical good results,complications,inhospital death,stent dysfunction,and month survival. Uni and multivariate Cox proportional hazard model was performed. Independent variables analyzed had been: age,sex,tumor etiology,amount of obstruction,baseline bilirubin,purpose for failed ERCP,days from onset of jaundice to drainage,days from failed ERCP to drainage,number of attempts,stent variety,price of internal biliary drainage,postprocedure chemotherapy. P . was deemed considerable. Benefits: Demographics: . male; mean (SD) age. years; . key MBO vs . metastatic; hilar vs distal MBO. Mean survival was days. Failed access towards the papilla as a purpose for failed ERCP was an independent predictive aspect of decreased postprocedure complication danger (OR IC . p.). Time from failed ERCP to final drainage procedure was an independente predictive aspect of elevated inhospital death threat (OR IC . p.). Hilar location was an PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/25611386 independent predictive factor of decreased and month survival (OR IC . p and OR IC . p.). Reintervention due to sent dysfunction was a predictor for elevated month survival (OR IC . p.). Hilar location and reintervention for stent dysfunction were independent predictors of mortality with time (HR IC . p. y HR IC . p.). EUSguided FNA will be the typical of care for tissue sampling of pancreatic lesions. It has some limitations for instance lack of appropriate Sodium Danshensu histology sample,low sensitivity for malignancy in the presence of chronic pancreatitis,low diagnostic accuracy within the absence of onsite cytopathologist and falsepositive rates up to . The new Echo Tip ProCore biopsy needle (Cook Healthcare) was created to acquire core tissue specimens improving the diagnostic yield and potentially obviating the need for onsite cytopathologist. Aims Techniques: To examine the typical Echo tip ultra FNAC needle with the new Echo Tip Ultra ProCore FNAB needle within the sampling of solid pancreatic lesions. Sampling time,quantity of passes and sample adequacy were compared. Randomized multicenter trial inside a tertiary university hospitals setting authorized by the National Study Ethics Service (NRES). All individuals referred for EUS guided tissue sampling of a solid pancreatic mass had been invited to participate. Informed consent type was obtained from just about every participant. Linear EUS (AlokaOlympus,HitachiPentax) was performed and sufferers have been randomised to either FNAC or FNAB. Due to the nature of your study the endoscopist could not be blinded. A G needle was employed when sampling from the stomach in addition to a G in the duodenum. A maximum of passeswere allowed. Sampling time from very first insertion from the needle in to the lesion to the time the final sample is transferred in to the histology pot,number of p.