A common image with the wellness status of the environment whereas exposure biomarkers have specificity of reaction (McCarthy and Shugart. Marine pollution monitoring programs are increasingly such as molecular,cell and tissuelevel biomarkers,applied in combination,for the assessment of the biological effects of pollutants (Den Besten ; Cajaraville et al. ; Viarengo et al. ; Knap et al. ; Marigomez et al. ; Orbea et al. ; Zorita et al. ; Hylland et al. ; Garmendia et al. a,b,c). As a result,biomarkers have provided usefulmechanistic facts to scientists,albeit the complete prospective of utilizing biomarkers in biological monitoring programs has been limited by the scarcity of integrated statistical analysis (Beliaeff and Burgeot. For the duration of the current final years,even so,biomarkers have been integrated in ecosystem health indices for simplicity purposes. The usage of these indices provides comprehensive details about the biological effects of pollution in marine organisms and may well therefore serve as helpful tools for environmental managers (Broeg and Lehtonen. The bioeffects assessment index (BAI; Broeg et ala modification of the “Health Assessment Index” (HAI; Adams et alwas made for the assessment of multifactorial contamination in coastal locations applying fishes as sentinels (Broeg et al BAI is defined as a “general health” index mainly because it comprises biomarkers of nonspecific toxic effects and responds to many different different contaminants (Broeg et al BAI was initial applied for the longterm study of the biological effects of pollution in the German Bight employing flounders (Platichthys flesus) as sentinels,and included deleterious effects at distinct levels of biological complexity,say: modifications in EROD activity,LMS,NL and macrophage aggregates in liver,too as diversity of parasitic fauna (Broeg et al BAI was also satisfactorily applied within the Baltic Sea (Broeg and Lehtonen,as a a part of the EUBEEP project,where biomarkers had been recorded in sentinel P. flesus,eelpouts (Zoarces viviparous) and blue mussels (Mytilus edulis). In mussels,the chosen biomarkers for the calculation of BAI have been LMS,NL and MN in digestive gland (Broeg and Lehtonen. The Wellness Status Index (HSI) is computed by an specialist system (ES) developed and created inside the BEEP framework to evaluate and integrate (impact and exposure) MedChemExpress 2,3,4,5-Tetrahydroxystilbene 2-O-D-glucoside responses of biomarkers (recorded at various levels of biological organization in mussels) to natural and contaminantinduced pressure (Viarengo et al. ; Dagnino et al The specialist method was initially applied applying biomarkers measured in caged mussels deployed along a pollution gradient near the Genoa Harbour (Dagnino et al Later on,it was satisfactorily applied in quite a few field and laboratory studies. Within the field,HSI was computed to integrate seven biomarkers recorded in PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/26698565 mussels caged along a copper pollution gradient within the Visnes fjord (Norway) (Dondero et al The professional program was also successfully applied to a set of biomarkers data from a biomonitoring study carried out about years ago within the pollution gradient along the Langesundfjord (Norway) (data from GESAMP workshop (Oslo; Dagnino et al Under laboratory conditions,the professional program was employed to integrate the responses elicited in biomarkers recorded in mussels exposed to crude oil,alkylated phenols and PAHs for days inside the RF RogalandI. Marigomez et al.Analysis Institute (Stavanger,Norway) (Dagnino et al In all cases,HSI computed by the expert system offered a clear indication on the.