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Of a large dosage.Pharmaceutics 2021, 13,13 ofBesides the inhaler attributes, this critique has focused attention on the function and on the significance in the capsule. The excellent capsules for inhalation must be able to meet the following criteria: capsule shells has to be capable of becoming either punctured or cut together with the minimum of shell particles becoming shed; within the case of pin puncturing, the flaps made will have to stay attached, stay open and not re-close or obstruct the powder emission; powders ought to empty from the shell with all the minimum of retention and there should be a minimum of interaction involving the shell as well as the fill material. These factors are influenced by the material they’re made of also as by the capsule moisture content material and also the degree of internal/external lubricant. Lastly, a reduction in shell moisture content material shouldn’t cause capsule brittleness.Author Contributions: F.B. Conceptualization, Supervision, Writing–original draft; E.Q. Visualization, Writing–original draft; C.A. Writing–review and editing and F.L. Conceptualization, Supervision, Writing–original draft. All authors have study and agreed to the published version of your manuscript. Funding: This investigation received no external funding. Institutional Review Board FPL64176 Autophagy Statement: Not applicable. Informed Consent Statement: Not applicable. Acknowledgments: The authors thank Qualicaps (Tokyo, Japan) and Capsugel (Colmar, France) for supplying capsule data. Conflicts of Interest: The authors declare no conflict of interest.AbbreviationsAPI cDPI COPD DPI FPD HPMC ICS LABA LAMA pMDI Active Pharmaceutical Ingredient Capsule-based Dry Powder Inhaler Chronic Obstructive Pulmonary Disease Dry Powder Inhaler Fine Particle Dose hydroxypropyl methylcellulose inhaled chorticosteroids 5-Pentadecylresorcinol Technical Information Long-acting beta(two) agonist Long-acting muscarinic antagonist Pressurised Metered Dose Inhaler
pharmaceuticsArticleConstruction of a Multifunctional Nano-Scale Metal-Organic Framework-Based Drug Delivery System for Targeted Cancer TherapyMengru Cai 1, , Yawen Zeng 1, , Manting Liu 1 , Longtai You 1 , Huating Huang 1 , Yang Hao 2 , Xingbin Yin 1 , Changhai Qu 1 , Jian Ni 1, and Xiaoxv Dong 1,2, College of Chinese Material Medica, Beijing University of Chinese Medicine, Beijing 102488, China; [email protected] (M.C.); [email protected] (Y.Z.); [email protected] (M.L.); [email protected] (L.Y.); [email protected] (H.H.); [email protected] (X.Y.); [email protected] (C.Q.) Division of Radiology, Division of Translational Nanobiomaterials and Imaging, Leiden University Healthcare Center, NL-2333 ZA Leiden, The Netherlands; [email protected] Correspondence: [email protected] (J.N.); [email protected] (X.D.) These authors contributed equally to this operate.Citation: Cai, M.; Zeng, Y.; Liu, M.; You, L.; Huang, H.; Hao, Y.; Yin, X.; Qu, C.; Ni, J.; Dong, X. Construction of a Multifunctional Nano-Scale Metal-Organic Framework-Based Drug Delivery System for Targeted Cancer Therapy. Pharmaceutics 2021, 13, 1945. https://doi.org/10.3390/ pharmaceutics13111945 Academic Editors: Patrick J. Sinko and Alyssa PanitchAbstract: The antitumor activity of triptolide (TP) has received widespread attention, despite the fact that its toxicity severely limits its clinical application. Thus, the design and style of a targeted drug delivery technique (TDDS) has vital application prospects in tumor treatment. Metal rganic frameworks (MOFs), with high drug-carrying capacity and very good biocompatibility, have arous.

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Author: haoyuan2014