E 1 (open stabilization): From the 15 subjects with cannabis use disorders, 53 no longer met the criteria for active cannabis abuse or had entered into early full remission. In the 9 subjects with cocaine use issues, 78 no longer met the criteria for active cocaine abuse or had entered into early full remission. When compared with baseline, a considerable in mood symptoms was observed for each interventions. Phase two (DB RCT): No differences in mood outcomes in between interventions.Prisciandaro et al., 2021 CannabisGabapentinGao et al., 2017  CannabisCannabis, Alcohol or bothQuetiapine XRKemp et al., 2009 Alcohol, cannabis, IEM-1460 manufacturer cocaineLithium vs. lithium valproateRapid cycling BD I or II Phase 1: N = 149; Phase two: N =6 months open label stabilization followed by six months DB RCT.Geller et al., 1998 Alcohol, Cannabis, InhalantsLithiumAdolescents with BD I or II, single manic episode, or MDD with at the least one predictor of future BD. N = 25, 2 on cannabis only and 14 on cannabis alcohol6 weeks DB, PLC controlled RCT add on to TAUThe lithium group showed considerable across mood and substance use outcome measures, in comparison with placebo. Little sample size, no separate outcome information reported for cannabis.Medicina 2021, 57,eight ofTable two. Cont.Substance Study Substances Intervention Bipolar Diagnosis and N Design and style 20 weeks DB, add on to anticonvulsants or antidepressants. No PLC manage six months open label stabilization followed by six months DB RCT. ten weeks DB, PLC controlled add-on to TAU 12 weeks DB, PLC controlled add-on to TAU 12 weeks DB, PLC controlled add-on to TAU Outcome/Limitations Each study medications were related using a significant in manic, depressive, or mixed mood states compared to baseline scores. Both medicines had been also related with drug cravings and use. Restricted evidence in the absence of a PLC handle. No separate outcomes had been reported for cocaine. See heading “Cannabis”. Phase 1 (open stabilization): Of 9 subjects with cocaine use issues, 78 no longer met criteria for active cocaine abuse or had entered into early full remission. No differences in mood outcomes and craving amongst lamotrigine and placebo. The lamotrigine group showed a higher in amount spent on cocaine. There had been no significant changes in psychiatric symptoms amongst groups. A important in the quantity of cocaine-positive urine screens was observed. Citicoline active cocaine use plus the likelihood of relapse. There was no considerable difference in craving symptoms in between groups. No important modifications in mood symptoms.Nejtek et al., 2008 Cocaine or methamphetamineQuetiapine or RisperidoneBD I or II. N =Kemp et al., 2009  Cocaine Brown et al., 2012  Brown et al., 2007  Brown et al., 2015 Alcohol, cannabis, cocaineLithium vs. lithium valproateRapid cycling Bipolar I or II disorder. Phase 1: N = 149; Phase two: N = 31 BD I, II, BD-NOS and cyclothymia, depressed or mixed, N = 120 BD I or II (history of at the very least one particular (hypo)manic episode. N = 44 BD I (depressed or mixed mood state) N =CocaineLamotrigineCocaine and at the very least on other SUDCiticolineCocaineCiticolineBD I: Bipolar I disorder; BD II: Bipolar II disorder; BD NOS: Bipolar Psalmotoxin 1 Autophagy disorder not otherwise specified; dACC: dorsal anterior cingulate cortex; DB: Double-blind; GBP: Gabapentin; IDS: Inventory of depressive symptoms; MDD: Important depressive disorder; PLC: Placebo; pMCC: posterior midcingulate cortex; rBG: appropriate basal ganglia; RCT: Randomized controlled trial; TAU Remedy as.