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Product Name :
PLGA-PEG-PLGA, custom synthesis

Classification :
PEG Copolymers / PLGA-PEG-PLGA, custom synthesis

Description :
PLGA-PEG-PLGA is an amphiphilic triblock copolymer consisting of a hydrophilic block polyethylene glycol (PEG) or polyethylene oxide (PEO) and a hydrophobic block poly(lactide-co-glycolide) (PLGA). The PEG polymer is capped a methyl ether group, and the hydrophobic block terminates with a hydroxyl group. PEGylated copolymers with biodegradable and biocompatible polyester segments can be used to prepare core-shell micelles, nanoparticles and microspheres. The hydrolytic degradability of polyester segments depend on the molecular weight and the spacer between ester groups (lactide, glycolide or caprolactone).PEG-PLGA can be dissolved in a range of common organic solvents depending on its composition especially the L to G ratio and the total PLGA MW. As the MW goes up and the content of G goes up, its solubility gets poor in common organic solvent. Typically PEG-PLGA at lower MW or greater L content can be dissolved in chlorinated solvents, such as dichloromethane or chloroform much easier, and sometimes in water-miscible solvents, like acetone, acetonitrile and THF depending on the total MW. PEG-PLGA with a higher amount of G is better dissolved by fluorinated solvents, like hexafluoroisopropanol. PEG-PLGA with other MWs is also offered.

Properties:
PLGA – poly(lactide-co-glycolide) copolymer are available at a wide range of molecular weight (MW) and monomer (lactide to glycolide) ratios. PLGA-PEG-PLGA can be dissolved in a range of common organic solvents depending on its composition especially the L to G ratio and the total PLGA MW. As the MW goes up and the content of G goes up, its solubility gets poor in common organic solvent. Typically PLGA-PEG-PLGA at lower MW or greater L content can be dissolved in chlorinated solvents, such as dichloromethane or chloroform much easier, and sometimes in water-miscible solvents, like acetone, acetonitrile and THF depending on the total MW. PLGA-PEG-PLGA with a higher amount of G is better dissolved by fluorinated solvents, like hexafluoroisopropanol and perfluoroacetone.

References:
1. Inhibition of Karyopherin beta 1 suppresses prostate cancer growth, Nature Oncogene, 2019, doi: 10.1038/s41388-019-0745-22. Strategies to enhance the distribution of nanotherapeutics in the brain, Journal of Controlled Release, 2017, 10.1016/j.jconrel.2017.07.028, Text.3. Indocyanine Green J Aggregates in Polymersomes for Near-Infrared Photoacoustic Imaging, ACS Appl. Mater. Interfaces 2019, 11, 50, 46437-46450, doi: 10.1021/acsami.9b145194. Biodegradable long-circulating polymeric nanospheres. Science 1994;363:1600–3, Text.Click here to view an expanded list of hundreds of publications citing Creative PEGWorks products.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
Related websites: https://www.medchemexpress.com/antibodies.html
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