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Product Name :
Cholesterol-PEG-Azide, MW 5k

Classification :
PEG Products / Cholesterol-PEG-Azide, MW 5k

Description :
Cholesterol-PEG-Azide uses very stable chemical bonds/linkage to attach cholesterol and azide to PEG through ether bond or amide bond. Unlike ester bonds which are prone to hydrolysis in aqueous solution, the ether linkage between cholesterol and PEG is chemically robust and very stable. Cholesterol is a membrane constituent which serves a unique function of modulating membrane fluidity, elasticity, and permeability. It fills in the gaps created by packing of other lipid species when proteins are embedded in the membrane. PEGylated cholesterol as an amphiphilic lipid derivative used to prepare liposome and other micelles as drug delivery systems.

Properties:
Molecular weight: MW of PEG was measured by MALDI-MS or GPC. PDI (polydispersity index) of our linear PEG is 1.02-1.05 with very narrow MW distribution. The number of repeating ethylene oxide units (CH2CH2O) or the degree of polymerization is calculated dividing the PEG MW by 44 (44 is the molecular mass of one repeating unit).Solubility: Soluble in water and aqueous buffer, chloroform, methylene chloride, DMF, DMSO, and less soluble in alcohol, toluene. Not soluble in ether.Density: PEG density is approximately 1.125 g/mLPhysical form: PEG products generally appear as white or off-white powder, and for very low MW linear PEG such as MW 1k or less, it may appear as wax-like, semi-solid material due to the low MW and the type of functional groups.Storage condition: PEG product shall be stored in the original form as received in a freezer at -20C or lower for long term storage. Stock solution of PEG reagents that do not contain oxygen or moisture sensitive functional groups may be temporarily stored in a refrigerator or ambient temperature for multiple days. Stock solution should avoid repeated freeze-and-thaw cycles. See Documents section for detailed storage and handling conditions.

References:
Click here to view an expanded list of hundreds of publications citing Creative PEGWorks products.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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