PLGA-PEG-COOH, PEG 5k & PLGA 20k, L:G 2:1

Product Name :
PLGA-PEG-COOH, PEG 5k & PLGA 20k, L:G 2:1

Classification :
PEG Copolymers / PLGA-PEG-COOH, PEG 5k & PLGA 20k, L:G 2:1

Description :
PLGA-PEG-Acid is a diblock copolymer with an acid group at the distal end of PEG. PEG-PLGA is an amphiphilic AB diblock copolymer consisting of a hydrophilic block polyethylene glycol (PEG) or polyethylene oxide (PEO) and a hydrophobic block poly(lactide-co-glycolide) (PLGA). The hydrophobic block terminates with a hydroxyl group. PEGylated copolymers with biodegradable and biocompatible polyester segments is useful to prepare core-shell micelles, nanoparticles and microspheres. The hydrolytic degradability of polyester segments depend on the molecular weight and the spacer between ester groups (lactide, glycolide or caprolactone). PEG-PLGA with other MWs as well as a variety of L to G ratio is also available through custom synthesis.

Properties:
PLGA – poly(lactide-co-glycolide) copolymer are available at a wide range of molecular weight (MW) and monomer (lactide to glycolide) ratios. PLGA can be dissolved in a wide range of solvents – higher lactide polymers can be dissolved using chlorinated solvents whereas higher glycolide polymers will require the use of fluorinated solvents such as hexafluoroisopropanol (HFIP) and perfluoroacetone.

References:
1). The MEK 1/2 inhibitor PD98059 exhibits synergistic anti-endometrial cancer activity with paclitaxel in vitro and enhanced tissue distribution in vivo when formulated into PAMAM-coated PLGA-PEG nanoparticles, Drug Delivery and Translational Research volume 12, pages1684–1696 (2022), Text.2) Biodegradable long-circulating polymeric nanospheres. Science 1994;363:1600Ã¢â‚¬“3, Text.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
Related websites: https://www.medchemexpress.com/antibodies.html
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Author: haoyuan2014

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