Product Name :
PLA-PEG-COOH, custom synthesis
Classification :
PEG Copolymers / PLA-PEG-COOH, custom synthesis
Description :
Acid and NHS ester functionalized PEG-PLA is a useful reagent to prepare core-shell nanoparticles with an amine-reactive maleimide for conjugation with peptide or proteins bearing free amine. PEG-PLA is an amphiphilic AB diblock copolymer consisting of a hydrophilic block polyethylene glycol (PEG) or polyethylene oxide (PEO) and a hydrophobic block polylactic acid or polylactide (PLA). The PEG polymer is capped a methyl ether group, and the hydrophobic block terminates with a hydroxyl group. PEGylated copolymers with biodegradable and biocompatible polyester segments can be used to prepare core-shell micelles, nanoparticles and microspheres.
Properties:
References:
1) Biodegradable long-circulating polymeric nanospheres. Science 1994;363:1600–3, Text.2) Preparation, characterization and properties of polylactide (PLA) – poly(ethylene glycol) (PEG) copolymers: a potential drug carrier. J Appl Polym Sci 1990;39: 1–9, Text.
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