Product Name :
URMC-099
Description:
URMC-099 is an orally bioavailable, brain penetrant mixed lineage kinase (MLK) inhibitor with IC50 of 19 nM, 42 nM, 14 nM, and 150 nM, for MLK1, MLK2, MLK3, and DLK, respectively. MLK3 activation is associated with many of the pathologic hallmarks of HAND and therefore represents a prime target for adjunctive therapy based on small-molecule kinase inhibition. In vitro, URMC-099 treatment reduced inflammatory cytokine production by HIV-1 Tat-exposed microglia and prevented destruction and phagocytosis of cultured neuronal axons by these cells.
CAS:
1229582-33-5
Molecular Weight:
421.54
Formula:
C27H27N5
Chemical Name:
5-(5-4-[(4-methylpiperazin-1-yl)methyl]phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-indole
Smiles :
CN1CCN(CC2C=CC(=CC=2)C2=CC3=C(NC=C3C3C=C4C=CNC4=CC=3)N=C2)CC1
InChiKey:
QKKIWEILHCXECO-UHFFFAOYSA-N
InChi :
InChI=1S/C27H27N5/c1-31-10-12-32(13-11-31)18-19-2-4-20(5-3-19)23-15-24-25(17-30-27(24)29-16-23)21-6-7-26-22(14-21)8-9-28-26/h2-9,14-17,28H,10-13,18H2,1H3,(H,29,30)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Emraclidine Biological Activity
Shelf Life:
≥12 months if stored properly.Belantamab In Vitro
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:31808802
Additional information:
URMC-099 is an orally bioavailable, brain penetrant mixed lineage kinase (MLK) inhibitor with IC50 of 19 nM, 42 nM, 14 nM, and 150 nM, for MLK1, MLK2, MLK3, and DLK, respectively. MLK3 activation is associated with many of the pathologic hallmarks of HAND and therefore represents a prime target for adjunctive therapy based on small-molecule kinase inhibition. In vitro, URMC-099 treatment reduced inflammatory cytokine production by HIV-1 Tat-exposed microglia and prevented destruction and phagocytosis of cultured neuronal axons by these cells.|Product information|CAS Number: 1229582-33-5|Molecular Weight: 421.54|Formula: C27H27N5|Chemical Name: 5-(5-4-[(4-methylpiperazin-1-yl)methyl]phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-indole|Smiles: CN1CCN(CC2C=CC(=CC=2)C2=CC3=C(NC=C3C3C=C4C=CNC4=CC=3)N=C2)CC1|InChiKey: QKKIWEILHCXECO-UHFFFAOYSA-N|InChi: InChI=1S/C27H27N5/c1-31-10-12-32(13-11-31)18-19-2-4-20(5-3-19)23-15-24-25(17-30-27(24)29-16-23)21-6-7-26-22(14-21)8-9-28-26/h2-9,14-17,28H,10-13,18H2,1H3,(H,29,30)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
