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Product Name :
β-Amyloid (12-20)

Description:
β-Amyloid (12-20) is a peptide fragment of β-Amyloid.

CAS:
134649-29-9

Molecular Weight:
1154.36

Formula:
C57H83N15O11

Chemical Name:
(2S, 5S, 8S, 11S, 14S, 17S, 20S, 23S, 26S)-20, 23-bis((1H-imidazol-4-yl)methyl)-26-amino-17-(3-amino-3-oxopropyl)-14-(4-aminobutyl)-2, 5-dibenzyl-11-isobutyl-8-isopropyl-27-methyl-4, 7, 10, 13, 16, 19, 22, 25-octaoxo-3, 6, 9, 12, 15, 18, 21, 24-octaazaoctacosan-1-oic acid

Smiles :
CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1C=CC=CC=1)C(=O)N[C@@H](CC1C=CC=CC=1)C(O)=O

InChiKey:
YEZCRNKNZWDABB-PZBWUIGESA-N

InChi :
InChI=1S/C57H83N15O11/c1-32(2)23-41(54(79)72-48(34(5)6)56(81)70-42(24-35-15-9-7-10-16-35)51(76)71-45(57(82)83)25-36-17-11-8-12-18-36)67-49(74)39(19-13-14-22-58)65-50(75)40(20-21-46(59)73)66-52(77)43(26-37-28-61-30-63-37)68-53(78)44(27-38-29-62-31-64-38)69-55(80)47(60)33(3)4/h7-12,15-18,28-34,39-45,47-48H,13-14,19-27,58,60H2,1-6H3,(H2,59,73)(H,61,63)(H,62,64)(H,65,75)(H,66,77)(H,67,74)(H,68,78)(H,69,80)(H,70,81)(H,71,76)(H,72,79)(H,82,83)/t39-,40-,41-,42-,43-,44-,45-,47-,48-/m0/s1

Purity:
≥98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Lansoprazole site

Shelf Life:
≥12 months if stored properly.

Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.

Additional information:
β-Amyloid (12-20) is a peptide fragment of β-Amyloid.|Product information|CAS Number: 134649-29-9|Molecular Weight: 1154.36|Formula: C57H83N15O11|Chemical Name: (2S, 5S, 8S, 11S, 14S, 17S, 20S, 23S, 26S)-20, 23-bis((1H-imidazol-4-yl)methyl)-26-amino-17-(3-amino-3-oxopropyl)-14-(4-aminobutyl)-2, 5-dibenzyl-11-isobutyl-8-isopropyl-27-methyl-4, 7, 10, 13, 16, 19, 22, 25-octaoxo-3, 6, 9, 12, 15, 18, 21, 24-octaazaoctacosan-1-oic acid|Smiles: CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1C=CC=CC=1)C(=O)N[C@@H](CC1C=CC=CC=1)C(O)=O|InChiKey: YEZCRNKNZWDABB-PZBWUIGESA-N|InChi: InChI=1S/C57H83N15O11/c1-32(2)23-41(54(79)72-48(34(5)6)56(81)70-42(24-35-15-9-7-10-16-35)51(76)71-45(57(82)83)25-36-17-11-8-12-18-36)67-49(74)39(19-13-14-22-58)65-50(75)40(20-21-46(59)73)66-52(77)43(26-37-28-61-30-63-37)68-53(78)44(27-38-29-62-31-64-38)69-55(80)47(60)33(3)4/h7-12,15-18,28-34,39-45,47-48H,13-14,19-27,58,60H2,1-6H3,(H2,59,73)(H,61,63)(H,62,64)(H,65,75)(H,66,77)(H,67,74)(H,68,78)(H,69,80)(H,70,81)(H,71,76)(H,72,79)(H,82,83)/t39-,40-,41-,42-,43-,44-,45-,47-,48-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: To be determined|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Anidulafungin Epigenetic Reader Domain |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|β-Amyloid Aggregation Guidelines (Following is our recommended protocol.PMID:33030073 This protocol only provides a guideline, and should be modified according to your specific needs). 1. Solid Aβ peptide was dissolved in cold hexafluoro-2-propanol (HFIP). The peptide was incubated at room temperature for at least 1h to establish monomerization and randomization of structure. 2. The HFIP was removed by evaporation, and the resulting peptide was stored as a film at -20 or -80 ℃. 3. The resulting film was dissolved in anhydrous DMSO at 5 mM and then diluted into the appropriate concentration and buffer (serum- and phenol red-free culture medium) with vortexing. 4. Next, the solution was aged 48h at 4-8 ℃. The sample was then centrifuged at 14000g for 10 min at 4-8 ℃; the soluble oligomers were in the supernatant. The supernatant was diluted 10-200-fold for experiments. Methods vary depends on the downstream applications.|References:| Stefania Sabella, et al. Capillary electrophoresis studies on the aggregation process of beta-amyloid 1-42 and 1-40 peptides. Electrophoresis. 2004 Oct;25(18-19):3186-94. Products are for research use only. Not for human use.|

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