Product Name :
DSPE-PEG-MAL, MW 3.4k
Classification :
PEG Products / DSPE-PEG-MAL, MW 3.4k
Description :
DSPE-PEG-MAL is a linear heterobifunctional PEGylation reagent with a DSPE phospholipid and a maleimide. It is a useful self-assembling reagent to prepare PEGylated liposome or micelle while also providing a thiol or cysteine reactive maleimide group. It is useful in targeted drug delivery with the lipid bilayer to improve drug solubility. PEG provides stealth property, extend circulation half-life and reduce non-specific protein binding or cell adhesion. The reactive maleimide bioconjugates targeting molecules including antibody, aptamer, protein, and peptide.
Properties:
Molecular weight: MW of PEG was measured by MALDI-MS or GPC. PDI (polydispersity index) of our linear PEG is 1.02-1.05 with very narrow MW distribution. The number of repeating ethylene oxide units (CH2CH2O) or the degree of polymerization is calculated dividing the PEG MW by 44 (44 is the molecular mass of one repeating unit).Solubility: Soluble in chloroform, methylene chloride, DMF, and DMSO. Lipid PEGs have enhanced solubility in alcohols and slightly soluble in ether with increasing solubility in ether with decreasing MW of PEG.Density: PEG density is approximately 1.125 g/mLPhysical form: PEG products generally appear as white or off-white powder, and for very low MW linear PEG such as MW 1k or less, it may appear as wax-like, semi-solid material due to the low MW and the type of functional groups.Storage condition: PEG product shall be stored in the original form as received in a freezer at -20C or lower for long term storage. Stock solution of PEG reagents that do not contain oxygen or moisture sensitive functional groups may be temporarily stored in a refrigerator or ambient temperature for multiple days. Stock solution should avoid repeated freeze-and-thaw cycles. See Documents section for detailed storage and handling conditions.
References:
1. Thiol PEGylation of Enzymes – Matrix Metalloprotease 2-Responsive Multifunctional Liposomal Nanocarrier for Enhanced Tumor Targeting, ACS Nano, 2012, 6 (4), pp 3491–3498, Text.2. Thiol PEGylation of Peptides – APN/CD13-targeting as a strategy to alter the tumor accumulation of liposomes, Journal of Controlled Release 154 (2011) 298–305, Text.3. Self-assembly and Thiol PEGylation – Vascular targeted single-walled carbon nanotubes for near-infrared light therapy of cancer, Nanotechnology 22 (2011) 455101, Text.4. Self-assembly and Thiol PEGylation – Targeting single-walled carbon nanotubes for the treatment of breast cancer using photothermal therapy, 2013 Nanotechnology 24 375104, Text.5. PEGylated Micelles and Thiol PEGylation – Aggregation-enhanced fluorescence in PEGylated phospholipid nanomicelles for in vivo imaging, Biomaterials 32 (2011) 5880e5888, Text.6. Intrinsically Zr-labeled Gd2O2S:Eu nanophosphors with high in vivo stability for dual modality imaging, Am JTransl Res, 2016;8(12):5591-5600. Text7. Effect of microRNA-129-5p targeting HMGB1-RAGE signaling pathway on revascularization in a collagenase-induced intracerebral hemorrhage rat model, Biomedicine & Pharmacotherapy, 2017, Pages 238-244, Text.8. Phosphatidylserine targeted single-walled carbon nanotubes for photothermal ablation of bladder cancer. Nanotechnology. 2017 Dec 13;29(3):035101. Text.9. GMBP1-conjugated manganese oxide nanoplates for in vivo monitoring of gastric cancer MDR using magnetic resonance imaging, RSC Adv., 2020, 10, 13687-13695, Text.10. Designed Ankyrin Repeat Proteins as Novel Binders for Ultrasound Molecular Imaging, Ultrasound in Medicine & Biology, 2021, Pages 2664-2675, Text.Click here to view an expanded list of hundreds of publications citing Creative PEGWorks products.
Related websites: https://www.medchemexpress.com/antibodies.html
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