Product Name :
Spastazoline
Description:
Spastazoline is a potent, cell-permeable and selective spastin (a microtubule-severing AAA (ATPases associated with diverse cellular activities) protein) inhibitor with IC50 of 99 nM for Human spastin. Spastazoline does not inhibit ATPase activity of a recombinant human VPS4 (another AAA protein required for intercellular bridge disassembly).
CAS:
2351882-11-4
Molecular Weight:
382.51
Formula:
C20H30N8
Chemical Name:
5-tert-butyl-N-2-[3-(propan-2-yl)piperazin-1-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl-1H-pyrazol-3-amine
Smiles :
CC(C)C1CN(CCN1)C1N=C(NC2C=C(NN=2)C(C)(C)C)C2C=CNC=2N=1
InChiKey:
HNOLTAKAPDKZRY-UHFFFAOYSA-N
InChi :
InChI=1S/C20H30N8/c1-12(2)14-11-28(9-8-21-14)19-24-17-13(6-7-22-17)18(25-19)23-16-10-15(26-27-16)20(3,4)5/h6-7,10,12,14,21H,8-9,11H2,1-5H3,(H3,22,23,24,25,26,27)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Spastazoline is a potent, cell-permeable and selective spastin (a microtubule-severing AAA (ATPases associated with diverse cellular activities) protein) inhibitor with IC50 of 99 nM for Human spastin. Spastazoline does not inhibit ATPase activity of a recombinant human VPS4 (another AAA protein required for intercellular bridge disassembly).|Product information|CAS Number: 2351882-11-4|Molecular Weight: 382.51|Formula: C20H30N8|Chemical Name: 5-tert-butyl-N-2-[3-(propan-2-yl)piperazin-1-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl-1H-pyrazol-3-amine|Smiles: CC(C)C1CN(CCN1)C1N=C(NC2C=C(NN=2)C(C)(C)C)C2C=CNC=2N=1|InChiKey: HNOLTAKAPDKZRY-UHFFFAOYSA-N|InChi: InChI=1S/C20H30N8/c1-12(2)14-11-28(9-8-21-14)19-24-17-13(6-7-22-17)18(25-19)23-16-10-15(26-27-16)20(3,4)5/h6-7,10,12,14,21H,8-9,11H2,1-5H3,(H3,22,23,24,25,26,27)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Solubility (25°C).Clarithromycin web 76 mg/mL(198.Ipratropium Biological Activity 68 mM).PMID:33140384 Insoluble.|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
